Medication-assisted treatment (MAT) can ease withdrawal and cravings when used safely and consistently. This page explains key guidelines for methadone and buprenorphine, including common interactions, side effects, and daily safety tips so you can stay stable and protect your health.
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Medication-assisted treatment combines medication with counseling and support. The medications used in MAT act on opioid receptors in controlled ways to reduce cravings and prevent withdrawal without causing euphoria. You’ll receive:
A carefully monitored medication dose
Regular medical oversight
Counseling and education
Ongoing dose adjustments as needed
This approach helps your body stabilize so you can focus on recovery and daily responsibilities.
Methadone is a long-acting opioid medication taken once daily in an opioid treatment program. When properly dosed, methadone helps you feel normal and functional, not high. It:
Buprenorphine is a partial opioid agonist with a ceiling effect. It’s often combined with naloxone to improve safety. This means:
Most side effects are mild and improve with dose adjustments. If side effects interfere with daily life, your provider can adjust your dose.
Possible methadone side effects include:
Possible buprenorphine side effects include:
Some medications and substances can interact with MAT medications and increase risks. Substances that may increase danger include:
Benzodiazepines such as Xanax or Valium
Alcohol
Sedatives or sleep medications
Certain pain medications
Use these basics to stay safe in treatment.
Once your dose is stable, most tasks are safe.
Take-home doses must be stored securely.
Methadone and buprenorphine are safe during pregnancy and breastfeeding when medically supervised. Treatment:
Receive a plan tailored to your needs and goals, with a steady, respectful approach that keeps you engaged in treatment.
Methadone and buprenorphine are available at BAART locations nationwide. Call to confirm options at the center nearest you.
All BAART centers are CARF-accredited and follow high standards for safe, ethical, evidence-based care.
We accept most private insurance. Veterans are eligible through the VA Community Care Network (Optum and TriWest) with prior authorization.
All BAART centers are federally certified, state licensed, and accredited by the Commission on Accreditation of Rehabilitation Facilities (CARF). This recognition reflects our dedication to quality care, continuous improvement, and the people we serve.
MAT works best when medications are used safely, consistently, and with support. If you have questions about methadone, buprenorphine, or medication interactions, BAART Programs can help you understand your options and take the next step with confidence.
Methadone and buprenorphine are used at therapeutic doses under medical supervision. They support stability and reduce harm rather than reinforcing opioid use.
Often, yes. Your provider will review possible interactions and adjust doses as needed to keep treatment safe.
There is no fixed timeline. Some people stay on MAT long term, while others taper gradually with medical guidance.
Stopping suddenly can raise overdose risk. Always talk with your provider before making changes to your medication.
